The ubiquitous neural cell adhesion molecule (N-CAM)
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چکیده
منابع مشابه
The ubiquitous neural cell adhesion molecule (N-CAM)
Adhesive interactions are important for cell trafficking, differentiation, function and tissue differentiation. Neural cell adhesion molecule (NCAM) is involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist but there are many ot...
متن کاملOligodendrocyte cell adhesion molecules are related to neural cell adhesion molecule (N-CAM).
The glycoproteins responsible for calcium-dependent oligodendrocyte aggregation were purified and characterized. Using detergent extraction, lentil-lectin-Sepharose 4B affinity chromatography, and preparative gel electrophoresis, 3 proteins were purified to apparent homogeneity, with relative Mrs of 120,000, 140,000, and 180,000. The aggregation assay showed that all 3 proteins had the ability ...
متن کاملThe neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions
On neural cells, the cell adhesion molecule L1 is generally found coexpressed with N-CAM. The two molecules have been suggested, but not directly shown, to affect each other's function. To investigate the possible functional relationship between the two molecules, we have characterized the adhesive interactions between the purified molecules and between cultured cells expressing them. Latex bea...
متن کاملTopographic localization of the heparin-binding domain of the neural cell adhesion molecule N-CAM
Previous studies have reported that the cell-binding region of the neural cell adhesion molecule (N-CAM) resides in a 65,000-D amino-terminal fragment designated Frl (Cunningham, B. A., S. Hoffman, U. Rutishauser, J. J. Hemperly, and G. M. Edelman, 1983, Proc. Natl. Acad. Sci. USA, 80:3116-3120). We have reported the presence of two functional domains in N-CAM, each identified by a specific mAb...
متن کاملAssociation between the first two immunoglobulin-like domains of the neural cell adhesion molecule N-CAM.
The extracellular domain of N-CAM contains five immunoglobulin-like (Ig) and two fibronectin type III-like domains and facilitates cell-cell binding through multiple, weak interdomain interactions. NMR spectroscopy indicated that the two N-terminal Ig-like domains from chicken N-CAM (Ig I and Ig II) interact with millimolar affinity. Physico-chemical studies show that this interaction is signif...
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ژورنال
عنوان ژورنال: Annals of Medicine and Surgery
سال: 2014
ISSN: 2049-0801
DOI: 10.1016/j.amsu.2014.06.014